Kendall Gorham ended the opener with a walk-off mercy-rule home run in the sixth and CBU held an 8-0 lead after three innings in the late game to end it in five.
The Lancers totaled 22 hits on the day, including a pair of homers from April Vasquez.
After loading the bases CBU added three more runs in the fourth inning.
Vasquez answered a Silversword run in the fifth with her first homer of the day, setting up Gorham's walk-off blast in the sixth inning.
Emma Holden moved her season record to 14-3 with another nearly un-hittable outing, giving up one run on two hits. A day after striking out nine batters in five innings of work, the Lancer ace fanned better than two batters per inning with 13 k's on Tuesday.
CBU waited until the second inning to get started in the late game, but poured in four runs on five hits to go up 4-0. Vasquez hit her second home run of the day and fifth of the season in the inning, getting things going with a two-run shot. Henry also had a two-run single in the inning.
Henry drove in four RBI on the day and Vasquez posted three.
Tory Ferreira went the distance in the nightcap, throwing five innings of three hit ball. Ferreira worked her way out of a jam to end the game in five, inducing a pop up to strand Silversword runners on second and third. Ferreira did not walk a batter in the game, moving her record to 14-2.
The Lancers are now 28-5 overall, 14-4 in the PacWest with the sweep. Chaminade falls to 6-16, 5-11.
CBU heads to Northern California once again for the Tournament of Champions hosted by Cal State Stanislaus.