It was the fourth time this season CBU has won by more than 20 points.
"I thought we played with more intensity tonight and just had a lot better all-around effort," said CBU head coach Jarrod Olson. "The turning point in my eyes was how we ended the half. That broke the game open for us and really hurt their spirit I think. We were able to pressure the ball there and really take them out of their rhythm."
Four straight costly turnovers late in the first half helped lead to nine straight points, putting the Lancers ahead 33-30 going into the break.
Lesley Vodicska kicked the run off with a three from the corner and then CBU scored on three straight fast breaks off of steals.
The Lancers were outshot in the first half, 44-36 percent, but grabbed three more rebounds and forced three more turnovers. Brittney Lewis scored 11 points for CBU in the opening period.
CBU kept the run going, scoring five straight out of the break as Vodicska hit her second three to put CBU up 38-30. A 19-4 run out of the gates gave CBU a 52-34 lead with just over 13 minutes to play.
The Lancers lead would only increase from there as they cruised to the 22-point victory.
Lewis led all players with 17 points in the game, Jasmine Beverly added 16 and Vodicska had 14 for CBU. Beverly also grabbed 10 rebounds for her third double-double of the season.
The Lancers held SBU to 28 percent shooting in the second half.
"Even though we scored pretty well tonight, I really thought our defense was the key," said Olson. "We were able to shut them down a little and that led to some offense. Once you get up by 15 or so that opens things up for people to start shooting more comfortably."
The win moves CBU to 7-2 on the season, while Southwest Baptist falls to 5-4.
CBU will be back in action following the Christmas break, picking conference play back up when they host Grand Canyon on Jan. 2.